Is Cannabis a Cure-all?

You might have seen in the media lately a lot of coverage about the use of cannabis to treat epilepsy and other conditions. It all started with the case of a young boy with severe epilepsy who was using cannabis oil to manage his seizures, with apparently great effect. Until, that is, his mother was unable to bring his treatment into the UK and his medication was seized at the airport.

These stories raise three questions:

  • What does UK law regulate in the case of medications based on cannabis
  • What is a cannabis oil?
  • Can cannabis treat any medical condition?

UK Law

In the UK, cannabis is a Class B drug – you aren’t allowed to possess or supply it and doing so can result in jail-time. This is a regulation under the Misuse of Drugs Act 1971, however cannabis is also regulated by The Misuse of Drugs Regulations 2001 which control the therapeutic use of drugs. Under this legislation, cannabis is regulated as a Schedule 1 drug which means it is not available for medical purposes and possession and supply are prohibited unless the Home Office approves.

cannabis plant seedlings

Cannabis: the sum of its parts

Cannabis refers to a group of plants which produce compounds called cannabinoids. Cannabis plants contain 113 different cannabinoids – so what exactly are we talking about when we talk about cannabis oil?

The two important cannabinoids to consider are tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main part of cannabis that gives its psychoactive effects. It’s the compound that will make you feel ‘high’ if you smoke marijuana although this response is mediated by other cannabinoids too. It also stimulates release of the hunger hormone, ghrelin, which explains why people have an increased appetite when they take cannabis. It does this by binding to a specific receptor on the surface of cells in the brain.

CBD is non-psychotropic and it acts in a very different way to THC. But it might also enhance THC activity by increasing the number of receptors available for THC to bind to. It might also increase the levels of those natural endocannabinoids in the body.

In the UK, CBD is legal which means cannabis oils containing only CBD are legally available whereas THC is not legal.

four brown glass unlabelled bottles containing oil

Can cannabis treat disease?

In the UK, there are already two cannabinoid based treatments licensed for prescription. Nabilone is used to treat nausea and vomiting in people undergoing chemotherapy. There are other conditions it has been indicated for including IBS, fibromyalgia, chronic pain and parkinson’s disease however in the UK it is only permitted to help treat the side effects of chemotherapy.

The second cannabinoid based treatment available in the UK is Sativex which is used to treat the symptoms of multiple sclerosis including neuropathic pain and spasticity. Sativex is a cannabis extract which contains both THC and CBD.

Cannabis for epilepsy

When it comes to epilepsy – there is considerable evidence that THC can control convulsions through regulation of neuronal excitability and inflammation. But because it can make you high – it’s not an ideal avenue for therapeutic exploration.

Research into CBD for treating epilepsy is relatively new but initially promising at least for certain types of epilepsy and there is a drug awaiting FDA approval which can treat Lennox-Gastaut syndrome and Dravet syndrome, two severe forms of epilepsy. But this might not be sufficient in all cases – some patients may require different mixtures of THC and CBD to see an effect.

Cannabis for cancer

Cannabis can be useful in managing cancer-associated side effects in patients. It can act as both a pain reliever and a way to reduce nausea and enhance appetite. But there is early research that it might also kill cancer cells and stop them growing. In these cases researchers have looked at highly purified THC and CBD. Some trials have shown that combining chemotherapy with cannabis might have some promise. However, we have insufficient evidence to support its use as a cancer treatment either due to small study sizes or the research predominantly taking place in cells in the lab which is just not a good representation of what would happen in humans. We don’t know which types of cannabinoids are most useful, what doses are needed, what types of cancer respond, how to take them effectively and whether they should or shouldn’t be combined with other treatments.

Cannabis research

If cannabis is so promising, why don’t we do more research on it to bring it to clinical trial? Cannabis is a Schedule 1 regulated drug, it can only be used in research with Home Office approval. Schedule 1 drugs are so classified because they are not deemed to have medical usefulness. But researchers like Professor David Nutt are concerned that the medical usefulness of cannabis cannot be proven if research is prohibited.

Importantly, the recent media interest in cannabis use as a medical treatment has been useful in encouraging a UK government review on the therapeutic value of medications based on cannabis. This review will be undertaken by the Advisory Council for the Misuse of Drugs and may lead to a change in the legal status of cannabis and cannabinoids with regards to their use in medicine.

A woman standing at a laboratory bench facing away from the camera and wearing a lab coat

Alternative medicine

In the meantime, it is important to remember that while cannabis holds some promise as a potential therapy for many conditions, it is crucial to always follow professional medical advice when considering medical treatments. The research supporting cannabis use is limited and there are many questions about safety and efficacy that remain unanswered. For many conditions that cannabis might be useful for, we already have good medical treatments that can be used before considering an as-yet, unproven treatment. Cannabis oils are poorly regulated and might have wildly variable levels of cannabinoids and may even contain ingredients that are harmful. It is never advisable to buy medical treatments online or take medical advice from someone other than a qualified medical professional.

 

I talked more about this on my podcast, Skeptics with a K – on this episode. You can follow me on Twitter @AliceEmmaLouise for more.

Top five ‘uses’ for crystals

I’ve been involved in skepticism for the last seven years. I’ve been one of the organisers for the Merseyside Skeptics Society for five years and a co-host of Skeptics with a K for three years. In this time of actively researching some of the more ridiculous pseudoscientific claims, one of the things I enjoy coming back to time and time again are the use of crystals.

Crystals epitomise many of the ‘appeals’ of pseudoscience. They’re natural, they’re ancient, they’re beautiful, they’re accessible and they’re easy. Speak to anyone who endorses the use of crystals as a way of healing and supporting your body and they’ll tell you that different crystals have different properties and can be used for different purposes. They’re a quick fix for your anxiety problems, they’ll bring you good luck for that job interview, they’ll even cleanse your chakras…

So here are my top five ‘uses’ for crystals.

  • The Jade Egg

This item hit headlines worldwide last year when Gwyneth Paltrow herself endorsed the use of jade eggs through her popular ‘wellness’ website, GOOP. The jade egg is a small piece of jade, shaped like an egg, that proponents recommend people who have a vagina should hold inside of their vagina. This ancient practice is recommended for supporting and training the pelvic floor or Kegel muscles. Jade is said to have properties which allow it to cleanse negative energy from the centre of “intuition, power, and wisdom” – the vagina. It should be said that not only is the use of jade for this is completely unsupported by the scientific evidence. It might also be actively detrimental for users. According to Dr Jen Gunter, gynaecologist and all-round gem (pun intended…) jade is particularly porous and therefore carrying a crystal inside the body can lead to bacterial infections developing in the vagina. Not to mention that over-enthusiastic Kegel training can actually cause pelvic pain for some women.

Claim: “Jade eggs can help cultivate sexual energy, clear chi pathways in the body, intensify femininity, and invigorate our life force. To name a few!”

Cost: A jade egg from GOOP will set you back $66

Why not? –  at worst it might lead to vaginal infections and pelvic pain at best, you’ve wasted your money on something that doesn’t work

  • Crystal Bed Therapy

At a New York City Wellness Centre called Modrn Sanctuary, you can immerse yourself in a crystal and energy bath using their Sensory 7 Energy Bath. For this experience you lay on an infrared biomat (whatever one of those is) with 17 layers of healing and immune system enhancing materials (apparently) and experience some ‘sound therapy’ from the sound system around the bed, ‘vibration therapy’ from the biomat, chromotherapy (which basically just means they will use coloured LED lighting to ‘adjust the vibrational frequencies in the body’) while zapping you with ‘frequencies’ and magnets to provide quantum magnetic pulses and frequency harmonising. Yes, it really is a bed combining all of the pseudoscience. In addition to all of this there are seven Vogel-cut quartz crystals which will apparently combine frequencies from the frequency generator, UV laser energy from the infrared biomat and the magnetic energy which apparently cancel each other out to leave TESLA ENERGY. Which is focused through the crystals into your chakras.

 

woman lying on a mat with a metal arm holding seven crystals above her. The crystals are lit and coloured red, orange, yellow, green, teal, blue and pink and are positioned down the centre of the body in a line from head to toe with even spacing
The Sensory 7 Energy Bath in use – image from Modrn Sanctuary.

Claim: Health! Wellness! Magic Tesla Energy…

Cost: $150 for one 60-minute session

Why not? – it shouldn’t do you any real harm, but you’ll be $150 and an hour of time down

  • Crystal Facial Roller

Facial rolling particularly with jade or rose quartz rollers is becoming increasingly popular in the beauty world. The premise is simple – you massage your face with a crystal roller. There are two suggested benefits from this. Firstly, believers claim that the massage of the face is good for reducing puffiness, preventing wrinkles and enhancing the skin. Secondly, some people believe that different crystals are imbued with different properties. So, jade is claimed to be a particularly cleansing stone and rose quartz apparently opens up the heart chakra bringing you love. There is, of course, no evidence that a) crystals have these properties, b) the body has any way, by chakras or any other means, of responding to these types of energy or c) that crystals have any ability to heal the body.

It seems slightly more plausible that massage of the skin might have some benefit in smoothing the skin however research shows that any benefit from facial massage is only subjective. A study of 142 women who received facial massage at beauty parlours showed that one third of patients had some negative effects including skin reddening, swelling or flare ups of dermatitis or acne following facial massage treatments.

Claim: facial rolling will reduce puffiness of skin and prevent wrinkles

Cost: you can get a jade roller for around £18

Why not? – it probably won’t cause any harm and it might feel soothing on the skin, but for some people it might trigger skin problem flare ups. The best way to protect your skin is to not smoke and to use a good sunscreen.

  • Crystal Butt Plugs

Yes, there are places on the internet where you can buy chunks of crystal to stick up your behind. Which would be completely fine if it weren’t for all the weird claims about chakras. According to Nymph NYC “black obsidian is definitely one of the strongest soul-cleansing stones” which “resonates with the root chakra”. According to Hindu tantrism the root chakra or Muladhara chakra resides below the coccyx which is why this company recommends the use of a butt plug in order to cleanse it. It shouldn’t need to be said that there is no evidence of the existence of chakra, no evidence that they need any sort of cleansing and no evidence that crystals can cleanse them.

Screen_Shot_2017-05-25_at_7.36.20_PM_1024x1024@2x
A black crystal butt plug on a pink background with iridescent glitter. Image from Nymph NYC.

Claim: “ORIGIN works energetically by bringing positive and nourishing energy to the root chakra at the buttocks while soaking up years of stagnant and settled negativity”

Cost: $135

Why not? – some crystals, such as jade, can be porous. It’s probably not a good idea to stick crystals in your anus. The rectum does not produce any natural lubrication and has very thin skin prone to tearing. Any insertion into this area should be gradual, with the use of a good quality lubricant to prevent damage.

  • Crystal Yoga

A common theme here is that many of these ideas combine pseudosciences. Now, I’m not saying that yoga doesn’t have its benefits. I practice yoga for my strength, flexibility and mental health. But the practice of yoga has its origins in the spiritual and some western yogis make some interesting health claims including that it can help with infertility despite no evidence to support these claims.

But some people claim that you can use crystals to ‘power up’ your yoga practice by lining them along or around your yoga mat. Do You Yoga claim that amethyst will help create serenity and stabilise emotions while moonstone will increase your wisdom. What’s more “If there is a specific stone that you’re attracted to or needing right now, carry it around somehow (pocket, locket, etc.), wear it as a pendant or even as a mala.” And don’t forget to ‘cleanse’ your crystal else it might hold onto negative energy.

Claim: ‘boost’ your yoga using crystals to “bring a new world of intentions, energies and powers into your life”

Cost: the cost of a crystal – this can range hugely from a few pounds to several thousand pounds.

Why not? – it probably won’t do you any harm, unless you fall or stand on a crystal during your practice!

 

What’s the most bizarre claim you’ve seen for crystals? Do you know anyone who carries crystals with them for luck? Let me know in the comments.

 

Kitchen cupboard “cures” – number one: turmeric

Wouldn’t it be great if we could cure all our ills with ingredients we can find in our kitchen cupboard? Plenty of people claim that it can be done and with the popularity of ‘natural’ medicines it’s not just your Nana who recommends it because that’s what her Nana taught her.

Kitchen cupboard remedies have become so mainstream that they become potentially dangerous when recommended for life-threatening diseases such as cancer. In fact, just a few months ago the Express asked “Can turmeric really cure cancer? Woman says benefits of golden spice ‘cured’ her disease”.

the express
Headline from the Express: “Can turmeric really cure cancer? Woman say benefits of golden spice ‘cured’ her disease”

But sometimes we wonder, if so many people believe it, maybe there’s really something in it?

In this series I will cover kitchen cupboard “cures” to investigate the claims made, and what the science really says. The series begins with the tasty Indian spice turmeric.

Turmeric

Turmeric is often reported as some sort of wonder spice. People who promote its use claim turmeric is anti-inflammatory, reduces cholesterol, treats diabetes, prevents Alzheimer’s disease and both prevents and cures cancer.

glass jar of orange coloured ground turmeric on a tea towel with a wooden spoon on the worktop next to it and turmeric on the spoon and counter

But actually, while this seems like a bizarre old wives’ tale, there is evidence supporting some of the claims for turmeric. The active ingredient in turmeric is curcumin or diferuloyl methane. Experiments in the lab show that curcumin alters the expression of genes in cells and some of these genes are related to specific pathways. For example, curcumin alters the expression of proteins related to inflammation in rat liver cells in a petri-dish and also alters the production of cholesterol in cells. Curcumin supplementation might also help manage some of the side effects of diabetes but only in conjunction with standard therapy. There is even some early evidence from mice with Alzheimer’s disease that curcumin can slow cognitive decline.

However, the science is also quite complicated. When it comes to cancer there is some evidence that curcumin can slow the growth of cancer cells in the lab but plenty of things slow cancer growth in the lab and never go on to prove useful therapies. Having said that, some clinical trials have shown that curcumin might one day prove useful as an adjunct to some cancer treatments in some cancer patients with some types of cancer.

The Express article above did discuss a case of a woman with myeloma, a type of blood cancer. This article was based on a single case published in British Medical Journal Reports in which a patient who had been on conventional treatment for many years suffered a relapse and was advised that there was nothing else doctors could do to help treat her cancer. The patient decided to take 8g chemical curcumin in tablet form per day in the hope it would treat her cancer. Her cancer has subsequently stabilised. This is a potentially interesting case – however it is only one single case that has been observed. Subsequent studies have not been done to investigate why this patient stabilised and there is insufficient evidence that it was the turmeric that was responsible. In fact, there are rare cases in which cancers such as myeloma can go into spontaneous remission without treatment and doctors believe this might be due to the patient’s own immune system targeting the cancer cells.

Important caveats

It would seem that the early research is fairly promising, however there are some very important caveats to remember here. So far, these studies are largely done in cells in a petri-dish or animals like mice or rats. We are not yet able to translate the findings to humans and we’re a long way from finding useful therapies using this compound.

Importantly, the studies use chemical curcumin rather than dietary turmeric and usually have specific measured doses. If curcumin becomes a useful therapy, the dose will change between different diseases and different patients. There is no evidence supporting the use of turmeric in isolation to treat disease. In all studies it is used as a supplement to standard therapy.

Clear capsules with orange powder inside

Medical treatments should always be managed by a medical professional. Any ‘herbal’ remedy has the risk of interacting with conventional drugs. In the case of curcumin research has shown that the chemical can inhibit some cancer treatments so it is important we understand the role curcumin plays in reacting with other medications before using this to treat patients.

It is because of this risk of interaction with other medications that it is really important patients taking any herbal remedy supplements speak to their doctors about whether these supplements might harm themselves or the efficacy of their treatments. It is important to note that many supplements are not fully regulated and therefore may contain ingredients that cause harm. For example, some curcumin supplements have been shown to contain anti-inflammatory drugs which can cause liver damage if taken in excess.

Summary: while there is some early evidence the active ingredient of turmeric might one day prove a useful supplement to conventional therapy we’re a long way from this being clinically useful. We need much more research to confirm the efficacy of curcumin and to establish which compounds work best and at which doses.

Next week I’ll be writing about Rosemary. If you have any specific requests for a Kitchen Cupboard “Cure” for me to cover, please leave a comment or send me a tweet @AliceEmmaLouise.

For more information on turmeric and cancer you can see CRUK’s review.

Sources:

 

 

 

Trends in Pseudoscience: Raw Water

Trend:

Water consciousness movement/raw water

What is it?

The water consciousness movement is a trend towards eschewing tap or bottled water for drinking and instead turning to unfiltered, unpasteurised, unsterilised spring water.

But why?

Proponents and, indeed, suppliers of this trend say that tap water in the US has been filtered – removing bacteria and minerals that they believe benefit the body. One supplier of ‘raw’ or ‘live’ water, Live Water, claims that “you can attempt to remineralize filtered water, but those minerals will never be bio-available like in fresh living spring water”. The bacteria content in ‘live’ water is lauded with Live Water announcing “there could be countless other beneficial microbes present, scientists just haven’t discovered yet”. They claim that beneficial bacteria, which they refer to as probiotics, are crucial for the proper digestion of food and the promotion of good health. Not only that but some raw water proponents are fearful of fluoride present in tap water. The founder of Live Water, Mukhande Singh, told The New York Times “Call me a conspiracy theorist, but it’s a mind-control drug that has no benefit to our dental health.”

And why not?

The filtering process applied to US tap water is and important step in making water that is safe to drink. It removes bacteria which can include organisms like E.coli but also parasites and viruses. A telling indication of the microorganisms present in ‘raw’ water comes from Mukhande Singh who told The New York Times of his company’s ‘live’ water: “If it sits around too long, it’ll turn green. People don’t even realize that because all their water’s dead, so they never see it turn green”. Water going green over time is a sure sign that something is growing in it. The water is alive, just not in the way that Mr Singh claims. Water borne diseases are not a problem for many Americans, these days, because we solved the problem with the availability of clean drinking water. The blight of the 1800s, cholera, a disease caused by water contaminated with a bacterium called Vibrio cholerae taught us a lot about the dangers of drinking unsanitary water. Sufferers of the ‘blue death’ often succumbed to a rapid death caused by severe dehydration, a consequence of incessant diarrhoea and vomiting.

Cholera_bacteria_SEM
Scanning electron micrograph of the rod shaped cholera bacteria (Vibrio cholerae). Source: http://remf.dartmouth.edu/imagesindex.html

US tap water is carefully regulated to ensure safe levels of microorganisms. US tap water is fluoridated which is scientifically proven to improve dental health. But there’s another benefit to drinking water that is regulated to prioritise health and safety. These regulations are subject to changes based on the evidence as our scientific understanding of certain contaminants develops. For instance, arsenic naturally occurs in water. Since the 1960s the regulations sustained arsenic below 50ug/L but by 2006 all drinking water in the US was required to have a level of 10ug/L or less. Studies show that this reduction in the regulated level in US drinking water has resulted in a reduction in the diagnosis of lung, bladder and skin cancer each year.

‘Raw’ water, is not regulated in the same way. The contamination of each ‘batch’ of water might not even be monitored. Not only might customers be drinking dangerous contaminants – they have no idea of which contaminants and at what level might be present in the ‘raw’ water they consume.

A list of alternative cancer therapies and a Good Thinking Society

Recently I worked on an interesting project with the Good Thinking Society.

The Good Thinking Society are a great charity who are small in size but are making great waves. The charity was founded by Simon Singh and their goal is “to encourage curiosity and promote rational thinking”.

One thing the Good Thinking Society does excellently is working in the medical field – they have been fundamental in changing the environment of NHS funding for treatments which lack scientific support for their use.

In 2010, The House of Commons Science and Technology Committee reported that homeopathy is no better than placebo. Despite this, this scientifically implausible treatment continued to be funded on the NHS to the tune of three to five million pounds per annum. This is a figure that the Good Thinking Society determined after working systematically through each CCG in the UK to identify which of them continued to fund homeopathy and how much they spent. Good Thinking Society supported many of those CCGs still funding homeopathy in reviewing their funding policies and succeeded in initiating the removal of this funding in many areas across the UK. They have also been instrumental in NHS England calling for homeopathy to be added to the NHS Blacklist of items which cannot be prescribed by GPs.

Good Thinking Society have some excellent resources on specific alternative therapies which you can find under their heading ‘Good Thinking About’. In particular they have an excellent primer on Gerson Therapy, a ‘treatment’ promoted as a cure for cancer which I have discussed here before.

Recently, I helped the Good Thinking Society compile a list of treatments which might be offered by alternative practitioners to vulnerable cancer patients. The list brings together a summary of the evidence for each treatment and outlines some of the potential risks and dangers of those treatments.

Here is a sample from this list:

Cancer list

Go take a look at their website and the list of alternative cancer treatments. And while you’re there – donate to their cause. They exist on donations and they need your support.

Science or Pseudoscience: Ancient Chinese Calligraphy Ink and Cancer Treatment

When it comes to reading about cancer cures in the media it is usually good advice to be pretty skeptical. Sometimes the story lends well to skepticism – like this one recently covered in a few outlets where it was proclaimed that scientists had found a cure for cancer in ancient Chinese calligraphy ink. It’s a story that has everything – including lasers. Here is a romantic idea that the cure for cancer might lie in an ink that is produced from plants and has been handed down between generations as a way to share writing and art. The proposed treatment is billed as non-invasive and specific only for cancer cells – could this really be science?

I was particularly suspicious when I saw that the representation of the story on Natural News, a prominent proponent of pseudoscience, looked a lot like the story on Science Alert which is typically more of a reliable source on science stories. So I did some digging into the data for this finding.

The paper that was covered in the media is titled “New Application of Old Material: Chinese Traditional Ink for Photothermal Therapy of Metastatic Lymph Nodes” and was published in the journal ACS Omega in August 2017. The researchers were based in Shanghai distributed across various institutes at different hospitals or universities. They had been working on a relatively new cancer therapy called Photo-thermal Therapy (PTT).

Photo-thermal therapy (PTT)

In cancer treatment, PTT is the use of specific types of nanoparticles to generate cell damaging heat specifically at the tumour sites. Scientists take a material that can be stimulated with light – typically infra-red – causing the generation of heat and subsequent tumour cell death. The problem is that many of these nanoparticles are toxic or expensive so in order to make the treatment as efficient and effective as possible, we need to find just the right material.

Hu-Kaiwen

Hu-Kaiwen (Hu-ink) is an ink that has been used by calligraphers in China for hundreds of years. It’s derived from plants, is mostly made up of carbon and it is black in colour which the materials used for PTT tend to be. So scientists got to wondering if it might be useful for PTT.

Firstly the authors of this study looked at the stability of the ink. They diluted it in different things including water and saline and made sure it was stable when stored over time. They looked at the structure of the ink and noticed that it typically forms small aggregates of 20-50nm in diameter – nanoparticles. They confirmed that the core component of the ink was carbon and they stimulated different concentrations of the diluted ink with infra-red lasers and tested the temperature. They found that Hu-ink was more efficient at converting light into heat than most other PTT materials reaching temperatures of 55°C after five minutes irradiation.

Hu-ink for PTT in cancer cells grown in the lab

In research we use cell models of cancer which we refer to as cancer cell lines. These are cells that have originally been taken from patients with different types of cancer but are grown and stored artificially in the lab. We use them so we can test things out on cells that behave like cancer but aren’t in a human body before we move on to doing tests in living organisms. The researchers in this study used some cancer cells originally derived from colon (SW-620) and colorectal (HCT-116) cancer. First they treated the cells with just the Hu-ink and the cells tolerated it really well proving that the ink solution itself wasn’t toxic. Then they treated the cells with the ink and combined it with irradiation with the infra-red laser.

Hu-ink
HCT-116 cells treated with Hu-ink and infra-red compared to HCT-116 cells treated with infra-red only. Image modified from the paper.

The image above is part of a figure taken from the paper itself. There are three images of HCT-116 colorectal cancer cells. In the top image, the cells were treated with only the laser for five minutes. They were not given any Hu-ink. In the middle image the cells were treated both with the Hu-ink at a medium dose for two hours and the laser for five minutes. In the bottom image the cells received a high dose of the Hu-ink for two hours and the laser for five minutes. The red cells are cells stained with a marker of cell death. The green cells are living cells. You can also see that the dead cells are much smaller than the living cells. In the top image where cells did not receive any ink – all of the cells are alive. In the bottom image where the cells had a high dose of ink – all of the cells are dead. In the middle image with a lower dose of the ink, there are some living cells and some dead cells. In other words – when you treat cancer cells with both Hu-ink and infra-red, the cancer cells die.

Hu-ink for PTT in mice

The researchers wanted to be sure that this technique was safe in living organisms and that it was able to kill cancer cells in living organisms. So they took mice with cancer of the lymph nodes and injected Hu-ink into the tumour which they then irradiated with infra-red. After an allocated treatment time, they removed the tumours from the mice and measured them.

Hu-ink2
Lymph node tumours taken from mice treated with Hu-ink and infra-red versus control treatments. Image modified from the paper.

For this experiment they had three control conditions – NS (the tumours were injected with saline), NS plus laser (the tumours were injected with saline and treated with a laser) and Hu-ink (the cells were injected with Hu-ink). They had one test condition – the Hu-ink plus laser. The test condition is the only one that the authors predicted would have an effect on tumour size. And that’s exactly what they saw. Lymph node tumours treated with Hu-ink and infra-red were significantly smaller than the control conditions. They also saw that the surrounding tissue wasn’t damaged suggesting that the treatment is safe.

Study conclusion

This study is a proof-of-principle study. The authors have shown that this ink can be used in PTT therapy with a positive effect and in a safe way in mice and in the lab. It is a very small scale study and it is a single study. It needs replicating before we can be confident in the result and it needs to be studied on a larger scale and have many more safety tests before we could begin to think about using it in patients. But it is a really promising study. It takes a treatment we already use and aims to make that treatment safer and cheaper and more available to patients. It is a non-invasive treatment and it can be used in ways that reduces tissue damage to healthy tissue while targeting cancer cells for cell death. It’s a great example of some really cool science, using materials that have been available for many years and applying them to modern techniques.

It might seem far-fetched to say ancient ink can help us treat cancer, but really it’s just cool science!

Report: Attendance at a Pseudoscience Lecture on Gerson Therapy

On Tuesday the 15th of August at a Holiday Inn conference room in Liverpool two of my colleagues from the Merseyside Skeptics Society and I attended a talk entitled “Censored for Curing Cancer”. Also in attendance were around 70 members of the public – some of whom were cancer patients.

The talk had been promoted as a tell-all in spite of censoring and was open to any member of the public through Eventbright ticketing for £20 in advance or for a cost of £30 on the door. The speaker, Patrick Vickers runs the Northern Baja Gerson Centre clinic in Mexico where, as Patrick described it, “we’re treating advance terminal diseases. Not just cancer but virtually every single disease we’re successfully treating, and we’re doing it with Gerson Therapy”.

I heard about the talk through social media, the poster was shared around by alternative medicine proponents with promises of an “epic story of Hope and Truth” about an “effective alternative therapy for advanced degenerative diseases including “terminal” cancer”. This is quite a bold – and scientifically testable – claim about a therapy that, despite the therapy having been around since the 1930s has no sound scientific evidence to support its efficacy.

Lvpool3
Image taken from the Northern Baja Gerson Centre website – a photo taken of the room during the talk in Liverpool on August 15th 2017.

What is Gerson Therapy?

Gerson Therapy is an alternative therapy pioneered by Max Gerson in the early 1900s based on an intense regimen of 13 organic juices, taken precisely on the hour, every hour, and following a strict protocol and a minimum of 5 daily coffee enemas. In addition to this demanding regime, patients must take a huge list of supplements including doses so high of potassium that (again quoting Vickers) “if a medical doctor learned how much potassium we give patients every day they’d be frantic” due to the risk of cardiac arrest.

The Gerson diet is specifically devoid of any salt other than that found in the juices and the patients must take castor oil – four tablespoons every other day in the first month, with a tapered reduction over the first months – in order to ‘detox’ from supposed toxins. The patients also take supplements of pancreatic enzymes and stomach enzymes as well as crude liver extract and niacin.

If all of that weren’t bad enough, Vickers’ clinic in Mexico offers a range of “adjuvant” therapies including rectal ozone, hydrotherapy in which they supplement heated water with hydrogen peroxide (bleach) and laetrile (made from apricot kernels and containing cyanide). All of this first takes place at the clinic during a minimum 2 week stay but Vickers’ goes to some length to stress that most people decide to stay for 3 weeks. This costs patients $5800 (over £4000) per week plus travel to Mexico. Not to mention the hundreds of pounds they will spend every month to continue the protocol for up to three years (or indefinitely) after they have left the clinic.

It is important to categorically state that there is no good evidence that the Gerson Therapy will cure cancer. However one foundation of our medical system is the right to informed consent – it protects the right of any individual patient of the age of consent to make a decision on the treatment path they follow; it protects the rights of any patient to follow alternative therapies should they so choose. But the most important element of that right is the informed part. The content of Patrick Vickers talk was fundamentally against adequate information provided to patients.

Encouraging a distrust in medical professionals

Even before beginning his talk, Vickers seeded distrust in medical professionals: he prefaced his 90 minute lecture with:

“I promise you, by the time you leave here today you will know more about cancer and reversing advanced degenerative disease than any medical doctor on the planet”.

To say this is hubristic is an understatement: a trained oncologist in the UK must undergo many years of training before they earn their specialism and must keep on top of the most up to date research in order to treat their patients to the standards expected by the NHS. This is not something that can be taught during a three hour public presentation. Even my own expertise in cancer research has taken five years to cultivate and I don’t have any responsibility to individual patients.

Compared to his later comments, Patrick’s insinuation that he can convey a complete understanding of one of the our most complicated range of diseases in the space of a single lecture might actually be one his more relatively mild transgressions – elsewhere in his presentation he advised a breast cancer patient to come off her Tamoxifen, told a set of parents that they should not take part in the immunotherapy trial they’d been offered, and told a blood cancer patient that she needed to be weaned off any medication she was taking if she were to undertake Gerson Therapy because it is “incompatible”. All of this “advice” was given with absolutely no understanding of the circumstances of those patient’s cases, since they were simply patients asking questions in the Q&A session after the talk, and the extensive patient history a medical professional with a duty of care would have needed before offering any advice was not be forthcoming in that setting.

Local media coverage

There was (at least) one patient in the room who might have been well known to Pat Vickers, however. Sean Walsh, a singer from Liverpool is a patient of the Northern Baja Gerson Centre clinic who has recently returned to Merseyside following his stay in Mexico. I first became aware of Sean when his story was hailed in the local media as an uplifting success because he survived longer than the 8 months his team of haematologists had predicted despite, eschewing their advice for his treatment and instead undergoing Gerson Therapy. The Liverpool Echo published a story about Sean headlined “Man with cancer beats 8 month prognosis despite shunning hospital treatment”.

At the time, I and my colleagues at the Merseyside Skeptics Society, along with a dozen cancer researchers from the University of Liverpool and North West Cancer Research, responded with a letter to the paper asking that they acknowledge their responsibility to not publish potentially dangerous information as though it were true despite the lack of evidence. The letter was published in the print edition of the Liverpool Echo.

LiverpoolEcho-Letters-20170227

What’s the harm?

According to Vickers’ seminar, should a patient decide to attend the Northern Baja Gerson Centre they would be taken off any conventional treatment they are already taking and weaned off any medication. He told the audience that it takes 3-6 months before a patient is ready to go on the full protocol due to an apparent risk of “chemotoxicity”, and then a further 6-12 months for the tumour to be “destroyed”.

He also recommend that patients on the treatment ought to have no scans in the first 6 months – a staggeringly dangerous message when a patient is stopping all conventional therapy and will have absolutely no indication of what the potentially lethal effect on their cancer during this crucial time period.

In my opinion, the danger of this lecture is threefold. Firstly, Vickers is directly claiming that Gerson Therapy will cure cancer. He says so categorically, and frequently. Not only is this dangerously untrue, but it almost certainly breaks the 1939 Cancer Act, which prohibits an “offer to treat any person for cancer, or to prescribe any remedy therefor, or to give any advice in connection with the treatment thereof”. The Act serves to protect the basis of informed consent fundamental to our medical system.

In addition to this, Vickers claimed that the media, the government and all of the medical professionals are lying about cancer treatment, stating, “It is important to know who is lying to you, how they’re lying to you, why they’re lying to you and when they’re lying to you”. He is promoting a potentially deadly distrust in the scientific consensus on effective cancer treatment, and what’s worse is that he makes these claims at a time when cancer treatment success has more than doubled in the UK in the last forty years. Scientific progress is huge in this area and promoting this distrust could have disastrous consequences for patients.

Thirdly, he is telling patients that the “only” way to cure cancer is the Gerson Therapy, and the only way to do this successfully is to spend thousands of pounds on a clinic stay, organic produce, juicing equipment, coffee enemas and supplements. Not only are some of these treatments dangerous in themselves, but the crippling costs can make the last few months of a patient’s life intolerably difficult, and the complicated and specific regime can make those last few months of a life unbearably miserable. To subject patients to that, on top of insisting that they have a three week stay in Vickers’ expensive clinic, often away from their family at a crucial time in their disease progression, is astonishingly irresponsible.

As a cancer researcher, I find it galling that this lecture can be hosted in a UK hotel with very little criticism. My concern is that information like this is at the very best, unethical and at the very worst leads to the unnecessary death of cancer patients in the region.